We now report that a single kinase, the mitogen-activated protein kinase kinase kinase dual leucine zipper-bearing kinase DLK , acts in the epidermis to promote the terminal differentiation of human keratinocytes. Articles by Germain, L. Google Scholar Articles by Robitaille, H. Prev Next Table of Contents. View this article with LENS.
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This Article First Published on January 28, doi: In the skin, epithelial cells undergo a terminal differentiation program leading to the formation of the stratum corneum. In support of this notion, we showed that DLK expression was restricted to the granular layer in situ.
Together these results identify DLK as a signaling molecule implicated in the regulation of keratinocyte terminal differentiation and cornification. Moreover the expression of wild-type DLK in keratinocytes stimulated transglutaminase activity and the consequent formation of the cornified cell envelope, while a kinase-inactive variant of DLK did not.
You’ll be in good company. Related Content Load related web page information. We now report that a single kinase, the mitogen-activated xlk kinase kinase kinase dual leucine zipper-bearing kinase DLKacts in the epidermis to promote the terminal differentiation of human keratinocytes.
Although it is expected that the last phases of this process must be tightly regulated since it results in cell death, the signaling pathways involved in this induction remain ill defined. Search for related content.
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Submit your work to JBC. In addition, 0800 keratinocytes infected with a recombinant adenovirus expressing DLK exhibited morphological and biochemical changes, including a suprabasal localization, altered cell shape, compacted cytoplasm, DNA fragmentation, and the up-regulation of filaggrin, that are reminiscent of a terminally differentiated phenotype.
Google Scholar Articles by Robitaille, H. Classifications Mechanisms of Signal Transduction.
View this article with LENS. Journal of Lipid Research.
To whom correspondence may be addressed: Prev Next Table of Contents. Abstract In the skin, epithelial cells undergo a terminal differentiation program leading to the dkk of the stratum corneum. Services Email this article to a friend Alert me when this article is cited Alert me if a correction is posted Alert me when eletters are published Similar articles in 80000 journal Similar articles in Web of Science Similar articles in PubMed Download to citation manager Request Permissions.